Biomedical Engineering

Faculty of Engineering, LTH

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Acoustofluidics papers

Peer reviewed publications related to acoustics in microfluidic systems @ BME Lund Univ.


  • Olof Gidlöf, Mikael Evander, Melinda Rezeli, György Marko-Varga, Thomas Laurell, David Erlinge, Proteomic profiling of extracellular vesicles reveals additional diagnostic biomarkers for myocardial infarction compared to plasma alone, Scientific Report, 2019, 9, 8991, DOI:
  • Franziska Olm, Anke Urbansky, Josefina H. Dykes, Thomas Laurell, and Stefan Scheding, Label-free neuroblastoma cell separation from hematopoietic progenitor cell products using acoustophoresis - towards cell processing of complex biological samples, Scientific Report, 2019,9, 8777 (2019), doi:10.1038/s41598-019-45182-3
  • Anson Ku, Naveen Ravi, Minjun Yang, Mikael Evander, Thomas Laurell, Hans Lilja, Yvonne Ceder, A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated urinary extracellular vesicle enrichment by acoustic trapping to microRNA sequencing, 2019, PLOS ONE, doi: 10.1371/journal.pone.0217507
  • Anke Urbansky, Franziska Olm, Stefan Scheding, Thomas Laurell and Andreas Lenshof, Label-free separation of leukocyte subpopulations using high throughput multiplex acoustophoresis, Lab Chip, 2019, 19, 1406
  • E. Hemachandran, S. Karthick, T. Laurell, and A. K. Sen, Relocation of coflowing immiscible liquids under acoustic field in a microchannel, Eur Phys Let, 2019, 125, 5, 54002, DOI: 10.1209/0295-5075/125/54002
  • Kerui Xu, Charles P. Clark, Brian L. Poe, Jenny A. Lounsbury, Johan Nilsson, Thomas Laurell and James P. Landers, Isolation of a Low Number of Sperm Cells from Female DNA in a Glass−PDMS−Glass Microchip via Bead Assisted Acoustic Differential Extraction, Analytical Chemistry 2019 5;91(3):2186-2191. doi: 10.1021/acs.analchem.8b04752
  • W. Qiu, J T. Karlsen, H Bruus, and P Augustsson, Experimental Characterization of Acoustic Streaming in Gradients of Density and Compressibility, 2019, Phys. Rev. Applied 11, 024018


  • Bryl-Gorecka P., Sathanoori R., Al-Mashat M., Olde B., Jögi J., Evander M., Laurell T. and D. Erlinge, Effect of exercise on the plasma vesicular proteome: a methodological study compaing acoustic trapping and centrifugation, Lab Chip, 2018,18, 3101-3111, DOI: 10.1039/C8LC00686E
  • Cushing K., Undvall E., Ceder Y., Lilja H., and T. Laurell, Reducing WBC background in cancer cell separation products by negative acoustic contrast particle immuno-acoustophoreis, Anal Chim Acta, 2018, 1000, 256-264, DOI: 10.1016/j.aca.2017.11.064 
  • Petersson K., Jakobsson O., Ohlsson P., Augustsson P., Scheding S., Malm J., Laurell T., Acoustofluidic hematocrit determination, Anal Chim Acta, 2018, 1000, 199-204, DOI: 10.1016/j.aca.2017.11.037 
  • Ku A., Lim HC, Evander M., Lilja H., Laurell T., Scheding S., and Y. Ceder, Acoustic enrichment of extracellular vesicles from biological fluids , Anal Chem, 2018, 90, 8011-8019, DOI: 10.1021/acs.analchem.8b00914 
  • Ohlsson P., Petersson K., Augustsson P. and Laurell T., Acoustic impedance matched buffers enable separation of bacteria from blood cells at high cell concentrations, Scientific Reports, 2018, 8:9156, DOI:10.1038/s41598-018-25551-0 
  • Karlsen J.T., Qiu W., Augustsson P., and Bruus P., Acoustic streaming and its suppression in inhomogeneous fluids, Phys Rev Lett, 2018, 120, 5, 054501


  • A. Urbansky, P. Ohlsson, A. Lenshof, F. Garofalo, S.Scheding and T. Laurell, Rapid and effective enrichment of mononuclear cells from blood using acoustophoresis, Scientific Reports, 2017, 7:17161
  • Cecilia Magnusson, Per Augustsson, Andreas Lenshof, Yvonne Ceder, Thomas Laurell and Hans Lilja, Clinical scale cell-surface marker independent, acoustic microfluidic enrichment of cancer cells from blood, Anal Chem, 2017, 89, 22, 11954-11961
  • Kevin W Cushing, Fabio Garofalo, Cecilia Magnusson, Lars Ekblad, Henrik Bruus and Thomas Laurell, Ultrasound Characterization of Microbead and Cell Suspensions by Speed of Sound Measurements of Neutrally Buoyant Samples, Anal Chem, 2017, 89, 8917−8923
  • Fabio Garofalo, Thomas Laurell and Henrik Bruus, Performance study of acoustophoretic microfluidic silicon-glass devices by characterization of material- and geometry-dependent frequency spectra, 2017, Phys. Rev. Applied 7, 054026 1-16
  • Maria Antfolk, Thomas Laurell, Continuous flow microfluidic separation and processing of rare cells and bioparticles found in blood – A review, Analytica Chimica Acta, 2017, 965, 9-35
  • Maria Antfolk, Soo Hyeon Kim, Saori Koizumi, Teruo Fujii, Thomas Laurell, Label-free single-cell separation and imaging of cancer cells using an integrated microfluidic system, Scientific Reports, 2017, 7, 46507    


  • Augustsson P., Karlsen J.T., Su H.W., Bruus H., and Voldman J., Iso-acoustic focusing of cells for size-insensitive acoustic-mechanical phenotyping, Nat. Com., 2016, 7, 11556
  • Jee-Woong Park , Su jin Lee , Ren Shuo, Soyoun Kim, Thomas Laurell; Acousto-microfluidics for screening of ssDNA aptamer, Scientific Reports, 2016, 6, 27121 
  • Pelle Ohlsson, Mikael Evander, Klara Petersson, Lisa Mellhammar, Ari Lehmusvuori, Ulla Karhunend, Minna Soikkeli, Titta Seppä, Emilia Tuunainen, Anni Spangar, Piia von Lode, Kaisu Rantakokko-Jalava, Gisela Otto, Stefan Scheding, Tero Soukka, Saara Wittfooth and Thomas Laurell; Integrated acoustic separation, enrichment and microchip PCR detection of bacteria from blood for rapid sepsis diagnostics, Anal Chem, 2016, 88, 19, 9403-9411
  • Jee-Woong Park, Soo Hyeon Kim, Takuro Ito, Teruo Fujii; SoYoun Kim,Thomas Laurell, SangWook Lee; Keisuke Goda, Acoustofluidic harvesting of microalgae on a single chip, Biomicrofluidics, 10, 034119 (2016)
  • Urbansky A., Lenshof A., Dykes, J., Laurell T., and Scheding S., Affinity Bead Mediated Enrichment of CD8+ Lymphocytes from Peripheral Blood Progenitor Cell Products using Acoustophoresis, Micromachines, 2016, 7, 101
  • Karlsen J.T., Augustsson P, and Bruus H., Acoustic force density acting on inhomogeneous fluids in acoustic fields, Phys Rev Lett, 117, 11, 114504
  • Marina C. Zalis, Juan F. Reyes, Per Augustsson, Staffan Holmqvist, Laurent Roybon, Thomas Laurell, Tomas Deierborg. Label-free concentration of viable neurons, hESC and cancer cells by means of acoustophoresis, Integrative Biology, 2016, 8, 332-340 


  • Soo Hyeon Kim, Maria Antfolk, Marina Kobayashi, Shohei Kaneda, Thomas Laurell, Teruo Fujii, Highly efficient single cell arraying by integrating acoustophoretic cell pre-concentration and dielectrophoretic cell trapping, Lab on a chip, 2015,  15, 4356-4363
  • Antfolk M., Magnusson C., Augustsson P., Lilja H. and T. Laurell, Acoustofluidic, Label-free Separation and Simultaneous Concentration of Rare Tumor Cells from White Blood Cells, Analytical Chemistry, 2015, 87, 9322-9328
  • Jakobsson O., Oh S.S., Antfolk M., Eisenstein M., Laurell T. and H.T. Soh, Thousand-fold volumetric concentration of live cells with a recirculating acoustofluidic device, Analytical Chemistry, 2015, 87, 8497-8502
  • Tenje M., Lundgren M.N., Swärd-Nilsson A-M., Kjeldsen-Kragh J., Åberg L. and A. Lenshof, Acoustophoretic removal of proteins from blood components, Biomedical Microdevices, 2015, 17:95
  • Evander M., Gidlof O., Olde B., Erlinge D. and T. Laurell, Non-contact acoustic capture of microparticles from small plasma volumes, Lab on a chip, 2015, 15, 2588-2596
  • Grenvall C., Magnusson C., Lilja H. and T. Laurell, Concurrent isolation of lymphocytes and granulocytes using prefocused free flow acoustophoresis, Analytical Chemistry, 2015, 87, 5596-5604
  • Antfolk M., Antfolk C., Lilja H., Laurell T. and P. Augustsson, A single inlet two-stage scoustophoresis enabling tumor cell enrichment from white blood cells, Lab on a chip, 2015, 15, 2102-2109
  • Tenje, M. Hongyan X., Evander M. Hammarstrom B., Tojo A., Belak S., Laurell T. and N LeBlanc, Acoustic trapping as a generic non-contact incubation site for multiplex bead-based assaysAnalytica Chimica Acta, 2015, 853, 682-688
  • Laurell T. and A. Lenshof, Microscale Acoustofluidics, Royal Society of Chemistry, 2015, ISBN:978-1-84973-671-8


  • Deshmukh S., Brzozka Z., Laurell T., and Augustsson P., Acoustic radiation forces at liquid interfaces impact the performance of acoustophoresis, Lab Chip, 2014, 14, 17, 3394-3400
  • Grenvall C., Antfolk C., Bisgaard C.Z. and T. Laurell, Two-dimensional acoustic particle focusing enables sheathless chip Coulter counter with planar electrode configuration, Lab Chip, 14, 4629-4637
  • Hammarstrom B., Nilson B., Laurell T., Nilsson J. and S. Ekstrom, Acoustic trapping for bacteria identification in positive blood cultures with MALDI-TOF MS, Analytical Chemistry, 2014, 86, 10560-10567, DOI: 10.1039/c4lc00572d
  • Lenshof A., Jamal A., Dykes J.,Urbansky A., Åstrand-Grundström I., Laurell T. and S. Scheding, Efficient purification of CD4+ lymphocytes from peripheral blood progenitor cell products using affinity bead acoustophoresisCytometry Part A, 2014, 85A, 933-941
  • Jakobsson O.J.E., Grenvall C., Nordin M., Evander M. and T. Laurell, Acoustic actuated fluorescence activated sorting of microparticles, Lab Chip, 2014, 14 (11), 1943-1950
  • Antfolk M., Barkholt Muller P., Augustsson P, Bruus H. and T. Laurell, Focusing of sub-micrometer particles and bacteria enabled by two-dimensional acoustophoresis, Lab Chip, 2014, 14(15), 2791-2799
  • Jakobsson O., Antfolk M. and T. Laurell, Continuous flow two-dimensional acoustic orientation of nonspherical cells, Analytical Chemistry, 2014, 86 (12), 6111-6114
  • Hammarström B., Evander M., Wahlström J. and J. Nilsson, Frequency tracking in acoustic trapping for improved performance stability and system surveillance, Lab Chip, 2014, 14, 1005-1013
  • Evander M. and M. Tenje, Microfluidic PMMA interfaces for rectangular glass capillaries, J. Micromechanics and Microengineering, 2014, 24, 027003










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