Tendons connect muscles to bones and are responsible for transferring mechanical loads and translating muscle contractions to joint movements. They can withstand high tensile loads and have complex load-dependent biomechanical properties. The Achilles tendon is the largest tendon in the body and the most commonly injured tendon. Treatments of ruptures is a complex medical problem that requires a controlled mechanical environment to restore the biomechanical strength and the load bearing capacity of the tissue. Understanding how loading can influence tendon homeostasis and healing is essential for maintaining and restoring the predominantly mechanical functions of tendons.
Our research is focused on the biomechanical behaviour of tendons and how these mechanical properties change due to loading and develop during healing, using both experimental and computational approaches.
Collaboration: The project is a collaboration with the Orthopaedics Department, Linköping University, Sweden.
Funding: Marie Curie Intra-European Fellowship for Career Development, Co-FUND Marie Curie project graduate school BioMEP.
Most recent publications:
Khayyeri, Blomgran, Hammerman, Turunen, Löwgren, Guizar-Sicairos, Aspenberg, Isaksson. Achilles tendon compositional and structural properties are altered after unloading by botox.https://www.ncbi.nlm.nih.gov/pubmed/29026107 Scientific Reports, 2017.
Turunen, Khayyeri, Guizar-Sicairos, Isaksson. Effects of tissue fixation and dehydration on tendon collagen nanostructure. Journal of Structural Biology, 2017.
Thompson, Bajuri, Khayyeri, Isaksson. Mechanobiological modelling of tendons: Review and future opportunities.Proc Inst Mech Eng H. 2017
Khayyeri, Longo, Gustafsson, Isaksson. Comparison of structural anisotropic soft tissue models for simulating Achilles tendon tensile behaviour. Journal of Mechanical Behavior of Biomedical Materials, 2016. (popular summary)
Khayyeri, Gustafsson, Heuijerjans, Matikainen, Julkunen, Eliasson, Aspenberg, Isaksson. A fibre-reinforced poroviscoelastic model accurately describes the biomechanical behaviour of the rat Achilles tendon. PLoSONE, 2015. (popular summary)