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Biomedical Engineering

Faculty of Engineering, LTH

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Our research

Videos introducing recent publications

In reading order:

Silva Barreto, Le Cann, Ahmed, Sotiriou, Turunen, Johansson, Rodriguez-Fernandez, Grünewald, Liebi, Nowlan, Isaksson. Multi-scale characterization of embryonic long bone mineralization in mice Advanced Science, 2020

Grassi, Fleps, Sahlstedt, Väänänen, Ferguson, Isaksson, Helgason. Validation of 3D finite element models from simulated DXA images for biofidelic simulations of sideways fall impact to the hip Bone, 2021

Gustafsson, Wallin, Isaksson. The influence of microstructure on crack propagation in cortical bone at the mesoscale Journal of Biomechanics, 2020

Grassi, Kok, Gustafsson, Zheng, Väänänen, Jurvelin, Isaksson. Elucidating failure mechanisms in human femurs during a fall to the side using bilateral digital image correlation Journal of Biomechanics, 2020

 

 

Bone mechanics

 Statistical modelling of shape and appearance of the hip

The research aims at improving osteoporosis diagnosis and fracture risk assessment. This is done by combining DXA imaging, a pre-developed shape template, statistical shape modeling, and finite element analysis (FEA).

Grassi, Fleps, Sahlstedt, Väänänen, Ferguson, Isaksson, Helgason. Validation of 3D finite element models from simulated DXA images for biofidelic simulations of sideways fall impact to the hip Bone, 2021

 

Damage mechanisms in healthy and osteoporotic bone

The research aims at understanding how the fracture resistance of bone is affected by age or disease and to identify what features that are key for maintaining good mechanical integrity. This is done using computational models such as the extended finite element model (XFEM).

Gustafsson, Wallin, Isaksson. The influence of microstructure on crack propagation in cortical bone at the mesoscale Journal of Biomechanics, 2020

 

 

Related projects

Assessment of bone quality during bone healing

The repair of fractures is not always straight forward and can lead to delayed healing and non-unions. Our group researches novel and better methods to assess the repair process. The research involves developing new methods for assessing bone quality with the help of various instruments at synchotron radiation and neutron spallation facilities in Lund and around Europe.

Related Projects

Understanding bone damage mechanisms

When affected by osteoporosis, bone becomes prone to fractures. Our research aims to comprehend the damage and failure mechanisms in bone on multiple lengthscales, to enable development of sophisticated methods for improving fracture risk assessment in osteoporosis.

Related Projects

Modelling of stress fractures in long bones

Stress fractures often occur in healthy active men and women, and are difficult to heal. Our research investigates the relationship betwee crack geometry and crack stress distribution, as well as tissue growth and remodelling.

 

Related projects

Modelling of Achilles tendon rupture and repair

Tendons rupture, healing and risk of re-rupture is a complex medical problem. Tendons have both elastic and viscoelastic properties, are transversely isotropic and are able to undergo large deformations. Our research focuses on computational modelling o f the tendon biomechanical properties to better understand the relationship between mechanical function and risk of rupture.

Related projects

Page Manager: Hanna Isaksson