Fracture repair is a highly complex process. Despite extensive research, delayed healing and non-unions are encountered in 5-10% of all fractures. Fracture healing is especially complicated in elderly patients with osteoporosis. Hence, effective treatments of fractures in these patients are essential. Recently developed drugs (bone morphogenetic proteins and bisphosphonates) have the potential to improve the healing outcome of these fractures. However, more in-depth analysis methods are needed to evaluate how the drugs affect the quality of the repaired bone tissue.
Our research aims to develop methods that can better assess bone quality, specifically in newly regenerated bone during fracture repair to determine the future potential of these novel biological drugs/treatments. In close collaboration with the Division of Orthopedics, we use three animal models; the bone chamber, the fracture healing model and the critical defect model in rats. The evaluation methods include micro-Computer Tomography (microCT), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), Fourier Transform Infrared Spectroscopy (FTIR), Small-Angle X-ray Scattering (SAXS) as well as mechanical testing (e.g. 3-point bending). Some of these experiments are being carried out using synchrotron facilities at MAX-IV in Lund, Sweden, and the Swiss Light Source (SLS) in PSI, Switzerland or neutron facilites at Swiss Spallation Source (SINQ) at PSI, Switzerland.
Funding: The project has earlier been funded by VINNOVA and the European Commission
Collaboration: The project is a collaboration with the Department of Orthopedics, and the Department of Physical Chemistry at Lund University,
Most recent publications:
Mathavan, Tägil, Isaksson, Do osteoporotic fractures constitute a greater recalcitrant challenge for skeletal regeneration? Investigating the efficacy of BMP-7 and zoledronate treatment of diaphyseal fractures in an open fracture osteoporotic rat model, Osteoporosis International, 28(2):697-707 2017
Mathavan, Turunen, Tägil, Isaksson, Characterising Bone Material Composition and Structure in the Ovariectomized (OVX) Rat Model of Osteoporosis, Calcified tissue international, 2015 (popular summary)